API INTERMEDIATES

API INTERMEDIATES

S.NoAPI NameIntermediate CAS NumberIntermediate NameTheraupatic CategoryQUOTE
1Celecoxib17852-52-74-Hydrazino Benzene Sulphonomide HCL (HBSH)Anti Inflammatory
2.1Dabigatran211915-84-3Ethyl 3-(2-(((4-cyanophenyl) amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo [d]imidazole-5-carboxamido)propanoateAntithrombotic
2.2Dabigatran211915-06-9Ethyl 3-[[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl] amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridine-2-yl)amino]propanoateAntithrombotic
3.1Dapagliflozin461432-22-45-Bromo-2-chlorophenyl) (4-ethoxyphenyl)methanoneAntidiabetic
3.2Dapagliflozin461432-23-521-(5-Bromo-2-chlorobenzyl)-4-ethoxybenzeneAntidiabetic
3.3Dapagliflozin461432-25-7[(2R,3R,4R,5S,6S)‐3,4,5‐tris (acetyloxy) ‐6‐{4‐chloro‐3‐[(4‐ethoxyphenyl) methyl] phenyl}oxan‐2‐yl]methyl acetateAntidiabetic
3.4Dapagliflozin461432-26-8(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxy benzyl)phenyl]-6-(hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triolAntidiabetic
4.1Dolutegravir1229006-21-6Methyl 5-(2,4-difluorobenzylcarbamoyl) -3-(benzyloxy)-1,4-dihydro-1-(2,2-dimethoxyethyl)-4-oxopyridine-2-carboxylate.Antiretroviral
4.2Dolutegravir1246616-66-9Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate. Antiretroviral
4.3Dolutegravir22483-09-62,2-DimethoxyethylamineAntiretroviral
4.4Dolutegravir188111-79-7(3R)-Amino- I -butanolAntiretroviral
4.5Dolutegravir1206102-11-5(4R,12aS)-N-(2,4-Difluorobenzyl)-7-benzyloxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide.Antiretroviral
4.6Dolutegravir1051375-16-6(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide.Antiretroviral
4.7Dolutegravir1051375-19-9Sodium (4R,12aS)-9-{[(2,4-difluorophenyl)methyl]carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1`,2`:4,5]pyrazino [2,1-b][1,3]oxazol-7-olate.Antiretroviral
5.1Empagliflozin86087-23-2(S)-(+)-3-HydroxytetrahydrofuranAntidiabetic
5.2Empagliflozin915095-85-1(5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanoneAntidiabetic
5.3Empagliflozin915095-89-5(3S)-3-{4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy}oxolaneAntidiabetic
5.4Empagliflozin915095-99-7(2R,3R,4R,5S,6S)-3,4,5-Tris(acetyloxy)-6-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]oxan-2-yl]methyl acetateAntidiabetic
5.5Empagliflozin864070-44-0D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-(1S)Antidiabetic
6.1Ezetimibe3382-63-6 4-[[(4-Fluorophenyl)imino] methyl]phenol Anti hyperlipidemic
6.2Ezetimibe189028-93-11-(4-Fluorophenyl)-5-[(4S)-2-oxo-4-phenyl- 1,3-oxazolidin-3-yl]pentane-1,5-dione Anti hyperlipidemic
6.3Ezetimibe1185883-40-2(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2[(S)-[(4-fluorophenyl)amino] (4-hydroxyphenyl)methyl}-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-oneAnti hyperlipidemic
6.4Ezetimibe163222-33-1(3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-oneAnti hyperlipidemic
7.1Linagliptin666816-98-48-Bromo-7-(2-butyn--1-ly)-3,7-dihydro--3-methyl-1H-purine-2,6-dioneAntidiabetic
7.2Linagliptin109113-72-62-(Chloromethyl)-4-methylquinazolineAntidiabetic
8.1Morpinum189400-21-3Olm inter-1Antihypertensive
9.1Olmesartan1446690-92-6Ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(2-trityl-2H-tetrazol-5-yl) phenyl] phenylmethyl} imidazole-5-carboxylateAntihypertensive
10.1Rivaroxaban438056-69-0,[4-(4-Aminophenyl)Moropholin-3-one],Antithrombotic
10.2Rivaroxaban161596-47-0([2-[(2S)-Oxiran-2-YlMethyl]-1H-Isoindole-1,3(2H)-DioneAntithrombotic
10.3Rivaroxaban24065-33-65-Chlorothiophene-2-carboxyilic Acid,Antithrombotic
10.4Rivaroxaban446292-07-52-[(2R)-2-Hydroxy-3-{[4-(3-oxomorpholin -4-yl) phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dioneAntithrombotic
10.5Rivaroxaban446292-08-62-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione446292-08-6Antithrombotic
10.6Rivaroxaban898543-06-14-{4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride.Antithrombotic
10.7Rivaroxaban366789-02-85-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin -4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide.Antithrombotic
10.8Rivaroxaban366789-02-85-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl) thiophene-2-carboxamide.Antithrombotic
11.1Sitagliptin764667-65-41-[3-(Trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo [4,3-a] pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butane-1,3-dione Antidiabetic
11.2Sitagliptin209995-38-02-(2,4,5-Trifluorophenyl)acetic acidAntidiabetic
11.3Sitagliptin762240-92-64 triazolo 4,3-a razine hydrochlorideAntidiabetic
11.5Sitagliptin486460-32-6(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5trifluorophenyl)butan-1-one Antidiabetic

Under Development

S#API IntermediatesCAS NUMBERDrug SubstanceQUOTE
1(4R,6S)-4-Hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide​147128-77-6​Dorzolamide Hydrochloride
2(R)-Dihydro-4-propyl furan-2(3)-one63095-51-2Brivaracetam
3(R)-2-(4-Aminophenethylamino)-1-phenylethanol hydrochloride​​521284-22-0 ​Mirabegron
4(R)-2-(4-Aminophenethylamino)-1-phenylethanol391901-45-4Mirabegron
54,6-Dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyridine)​75438-54-9Moxonidine​
62-Amino-5-benzylmercapto-1,3,4-thiadiazole ​25660-71-3Methazolamide
&
Acetazolamide​
72-Acetylamino-5-benzylmercapto-1,3,4-thiadiazole64387-67-3Methazolamide
&
Acetazolamide​
85-Acetylimino-4-methyl-2-benzylmercapto-1,3,4-thiadiazole95046-30-3​Methazolamide
&
Acetazolamide​
9(E)-3-(4-amino-3,5-dimethylphenyl) acrylonitrile hydrochloride661489-23-2Rilpivirine Hydrochloride
10Ethyl 7-chloro-2,2-dimethylheptanoate​2570179-39-2​Bempedoic Acid
114,6-dichloro-2-(propylthio)pyrimidin-5-amine​145783-15-9​Ticagrelor​
122-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3] dioxol-4-yl)oxy)ethanol L-Tartrate​376608-65-0Ticagrelor​
132-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol​376608-74-1Ticagrelor​
141-(5-Bromo-2-chlorobenzyl)-4-ethoxybenzene​461432-23-5Dapagliflozin
&
Ertugliflozin​
15(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate​

[Dapagliflozin Tetracetate]​
461432-25-7​Dapagliflozin
&
Ertugliflozin​
165-Chloro-2-Nitro-N-phenylaniline​25781-92-4​Clobazam​
175-chloro-N-phenylbenzene-1,2-diamine​68406-47-3​Clobazam​
18Ethyl 3-((4-chloro-2-(phenylamino)phenyl)amino)-3-oxopropanoate​22316-45-6​Clobazam​
19Nor-Clobazam22316-55-8​Clobazam
20Clobazam22316-47-8Clobazam
213-Amino-4-(methylamino)benzoic acid​66315-15-9Dabigatran Etexilate Mesylate​
22N-(4-Cyanophenyl)glycine42288-26-6​Dabigatran Etexilate Mesylate​
23Ethyl 3-(pyridin-2-ylamino)propanoate​103041-38-9​Dabigatran Etexilate Mesylate​
24Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate​212322-56-0​Dabigatran Etexilate Mesylate
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